Pathogenesis of spondylarthropathies

Immunologic and genetic links between spondylarthropathies and inflammatory bowel diseases.

BACKGROUND AND OBJECTIVE Spondyloarthritis (SpA) is a well recognized extraintestinal manifestation of Inflammatory Bowel Diseases (IBDs), either Crohn's Disease(CD) or Ulcerative Colitis (UC). A much larger percentage of SpA patients have subclinical gut inflammation manifested either by endoscopic findings or by histology. The aim of the present article is to review clinical and experimental ...

Pathogenesis of Epilepsy: Challenges in Animal Models

  Epilepsy is one of the most common chronic disorders affecting individuals of all ages. A greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. Therefore, severa...

The Immunological Basis in the Pathogenesis of Gout

Low dose of infliximab is inadequate in most patients with spondylarthropathies.

OBJECTIVES The recommended starting dose for infliximab for ankylosing spondylitis 5mg/kg is higher than that for rheumatoid arthritis. Because of the high expense of the drug lower doses may be considered. We report our experience with lower initial doses. METHODS Thirty patients with active SpA (16 psoriatic arthritis, 12 ankylosing spondylitis and 2 undifferentiated) received 6 infliximab ...

Transient efficacy of pulse pamidronate treatment in active spondylarthropathies: an open study of 35 cases.